EGFR and colorectal carcinoma: When intersecting the significantly targeted genes in DLD-1 KRASwt/- and RKO BRAFwt/-/- cell systems to pinpoint drivers in both genetic backgrounds, 483 genes were identified (Additional file 1: Table S3) with enrichment in CRC pathways such as Wnt, ErbB, and MAPK (P = 5.23 × 10–5, 0.0045, and 0.046; Additional file 1: Table S4).