EGFR and cancer: A combined literature and pathway analysis showed that: (1) 31% of the 163 genes were recurrently mutated in human cancers (P = 8.05 × 10–47 under the assumption of 400 cancer genes of 20,000 total protein-encoding genes, hypergeometric distribution); (2) 19% had previously been linked to the EGFR/Ras/MAPK pathway and 6% to the associated Hippo pathway; and (3) 11% had been linked to intracellular glucose metabolism.