We used Pa-LPS instillation into the murine lungs to trigger inflammatory-oxidative stress as observed in the CF-airways and demonstrated here the pharmacological potential of SAHA in controlling the Pa-LPS induced inflammatory cytokine, IL-6 and MPO (neutrophil activation marker, Fig. 2a-d) levels, suggesting its anti-inflammatory potential. The gene discussed is MPO; the disease is cystic fibrosis.