Our data supports this hypothesis as we observed that SAHA modulates Pa-LPS mediated changes in the anti-oxidant Nrf2 (in Cftr+/+ mice) and NFκB (inflammation) (Fig. 2e, f and Fig. 4c, d), which indicates towards its potential utility in controlling inflammatory-oxidative stress in the CF-airways that requires further experimental validation. The gene discussed is NFKB1; the disease is cystic fibrosis.