HDAC6 and cystic fibrosis: Here, we demonstrate that HDACi using SAHA (or tubacin), or shRNA mediated HDAC6-knockdown, significantly controls cigarette smoke extract (CSE) exposure induced ER-stress activity (Additional file 1: Figure S1A and B), suggesting the potential of selective HDACi in reducing the misfolded ΔF508-CFTR induced ER-stress in the CF-airways.