Hence, we demonstrate here that HDACi using SAHA can also restore sub-chronic CS (sc-CS) mediated decrease in T-reg cell numbers (Additional file 1: Figure S1C), suggesting that SAHA treatment might be beneficial in controlling inflammation in disease states with acquired CFTR-dysfunction, such as chronic obstructive pulmonary disease (COPD). This evidence concerns the gene CFTR and chronic obstructive pulmonary disease.