The EMPA-REG OUTCOME trial reported reduced death from cardiovascular causes, and decreased hospitalization for heart failure and progression to end-stage kidney disease, in patients with type 2 DM treated with SGLT-2 inhibitors, and established that there was a decreased risk of re-hospitalization for heart failure and the occurrence of myocardial infarction [13]. This evidence concerns the gene SLC5A2 and heart failure.