LEP and breast carcinoma: In 2012 ten potential cancer serum biomarkers (Osteopontin, Haptoglobin, CA15–3, Carcinoembryonic Antigen, Cancer Antigen 125, Prolactin, Cancer Antigen 19–9, α-Fetoprotein, Leptin and Migration Inhibitory Factor) were studied to predict early stage breast cancer in samples collected before clinical diagnosis, but it was not possible to accurately differentiate samples from controls from those patients, [11].