This phenomenon is distinct from the reduction of expression of GRHL1 and GRHL3 genes in tumor samples in comparison with the adjacent healthy epidermis, as reduced Grhl3 mRNA levels were observed in SCC samples in the Grhl3+/+ (wild-type) mice, which did not have any mutations or polymorphisms in the Grhl3 gene [5]. This evidence concerns the gene GRHL3 and neoplasm.