GRM7 and noise induced hearing loss: The gene-by-gene interaction data obtained through the software of GMDR showed that the best model made up of rs11920109, rs1485175, rs9826579, suggesting that the main effect of the GRM7 gene on susceptibility to NIHL we have found is the combination of these three genes; that is, the influence of rs1485175 on NIHL is dependent on the genotypes of the other two SNPs in GRM7.