The results of APOE-related cholesterol response to hypolipemic treatment in hypercholesterolemic AD patients revealed that in absolute terms all APOE variants respond similarly (RR > 70%) to treatment, with a significant reduction in CHO levels (p < 0.001) (Figure 7); however, genotype-related correlation analysis case by case (Figure 8) and comparative correlation analyses of APOE variants show a clear differential APOE-related pattern of CHO response to treatment [17]. Here, APOE is linked to Alzheimer disease.