PTGS2 and cancer: The potential chemopreventive role of curcumin in cancer prevention has been reported in a mouse skin model [77], and in epithelial colon cells [78] by inhibition of cyclo-oxygenase 2 (COX2) expression through inhibition of κB degradation by downregulation of NF-κB-inducing kinase (NIK) and IκB kinase (IKK) α/β.