PTGS1 and infection: The results of the immunohistochemical reactions showed that in Acanthamoeba-infected immunosuppressed mice during infection, the lungs exhibited changes in COX-1 (Figure 6G–L, respectively) and COX-2 (Figure 7G–L, respectively) expression in comparison to the control group (Figure 6 and Figure 7A–C) and the uninfected immunosuppressed mice (Figure 6 and Figure 7D–F).