However, Xu et al., reported that combined treatment with curcumin and temsirolimus in Caki-1 and OS-RC-2 RCC cell lines markedly upregulates YAP, which binds to p53 promoter, enhances p53 expression and finally induces apoptosis by activation of cleaved poly ADP-ribose polymerase (PARP) and caspase 3, and downregulation of BCL-2 protein expression [115]. This evidence concerns the gene TP53 and renal cell carcinoma.