Here we report the work of ClinGen’s Inherited Cardiomyopathy Expert Panel (CMP-EP), which adapted the ACMG/AMP framework for use in myosin heavy chain 7 (MYH7)-associated cardiomyopathies with the aim of improving consistency for variant interpretation and expert curation of reported MYH7 variants for submission to ClinVar (3 star). This evidence concerns the gene MYH7 and cardiomyopathy.