AQP7 and obesity due to melanocortin 4 receptor deficiency: In summary, taking into account that these studies were not designed to identify if a changed AQP7 abundance would be a cause or a consequence of obesity or T2D, and that most of them were conducted in mixed gender cohorts, the results agree with an association between reduced AQP7 abundance and obesity, whereas a direct association between dysregulated AQP7 abundance and T2D seems less evident.