EGFR and AIDS dementia complex: Among these putative sites, the residues Y39, Y125, Y133 and Y136 are the most likely targets for phosphorylation by EGFR (Figure 5D), suggesting that SNCA could act as a promising target of the oncogenic receptor tyrosine kinase EGFR. Taken together, all the findings mentioned above demonstrated a link between SNCA and the EGFR signaling pathway in ADC.