In experimental settings, VEGF-D promoted angiogenesis and lymphangiogenesis within and at the periphery of solid tumors, as well as enhancing solid tumor growth and metastatic spread to lymph nodes and distant organs, in a range of mouse cancer models including transgenic, gene ablation and xenograft models [1,32,67,68,69,70,71]. The gene discussed is VEGFD; the disease is cancer.