Given that VEGF-C and VEGF-D can activate signaling for proliferation of vascular endothelial cells and angiogenesis [2,64], and have been reported to promote edema in certain animal models [54,65], there has been interest in targeting these growth factors in wet AMD as a strategy to further enhance the restriction of pathological neovascularization and vascular leakage achieved with currently used drugs. This evidence concerns the gene VEGFC and wet macular degeneration.