VEGF-D, as well as VEGF-C, were recently shown to play a potential role in lymphangiogenesis in ovarian cancer as the secreted protein acidic and rich in cysteine (SPARC), a calcium-binding glycoprotein, appears to function as a tumor suppressor in this disease by inhibiting angiogenesis and lymphangiogenesis by reducing expression of both VEGF-C and VEGF-D [77]. This evidence concerns the gene VEGFD and ovarian carcinoma.