CD44 and central nervous system cancer: Using this approach, Kumar’s group demonstrated that an increase in ECM stiffness induces both proliferation and motility of glioma cells [51] and that the signalling pathways involved in the mechanotransduction include non-muscle myosin II [51], α-actinin [150], talin [151] and Rho GTPase RhoA [152] and are often driven by EGFR, CD44 and integrins [37,153,154].