CGAS and HIV infectious disease: Our screen identified sequence divergence in a number of proteins that are important during HIV infection, such as APOBEC3C (91.6%) and BST2 (also known as tetherin, 95.1%), as well as pattern-recognition receptors (MBL2, CLEC4A, CLEC4D and CLEC6A), the antiviral sensor cyclic GMP–AMP synthase (cGAS (also known as MB21D1)) and other immune mediators (Extended Data Table 1).