The AMI patients with severe AKI were older women with diabetes mellitus, stroke history, malignant arrhythmias/cardiac syncope/cardiogenic shock attack, hyperuricemia, lower albumin, advanced Killip class, low blood pressure and impaired kidney function at the time of admission, and had not received medicine therapy (including aspirin, β-blocker and ACEI/ARB therapy) and interventional or coronary artery bypass graft therapy. The gene discussed is ALB; the disease is diabetes mellitus.