Partial inactivation of Cn in both sporadic and familial ALS patients as well as in an asymptomatic carrier of a dominant SOD1 mutation may suggest the role of Cn in the pathogenesis of ALS [15].Both Cn and SOD1 are zinc (Zn)-containing metalloproteins [16–21]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.