Dr. Maurice Tangui from the University of Montpelier (France) provided an overview on the sigma-1 receptor (S-1R) agonists because of their cytoprotective action in different neurodegenerative pathologies including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), or stroke. Here, TMBIM4 is linked to Alzheimer disease.