According to the eighth report of the Joint National Committee (JNC 8); in the general non-black population, including those with diabetes, initial antihypertensive treatment should include a thiazide-type diuretic, calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs); whereas in the general black population, including those with diabetes, initial antihypertensive treatment should include a thiazide-type diuretic or CCB. The gene discussed is ACE; the disease is diabetes mellitus.