TNF and soft tissue sarcoma: In such cases, no standard treatment exists.<h4>Case presentation</h4>We report on a case of malignant advanced OFMT of the hand with lung metastases responding to isolated limb perfusion with human recombinant tumor necrosis factor and melphalan and chemotherapy with epirubicin and ifosfamide.<h4>Conclusions</h4>To our knowledge, this is the first report of activity of soft tissue sarcoma-oriented chemotherapy in advanced OFMT.