PDCD1 and melanoma: IPRES signatures, a set of 26 transcriptomic signatures, were found co-enriched to improve resistance to PD-1/PD-L1 blockade in tumors form nonresponding melanoma patients and the upexpression of IPRES related to the regulation of mesenchymal transition, cell adhesion, extracellular matrix (ECM) remodeling, angiogenesis and wound-healing [121].