MMP2 and esophageal squamous cell carcinoma: The C→T transitions at -1306 and -735 in the MMP-2 promoter eliminate a Sp1-binding site (CCACC box), thereby decreasing MMP-2 transcription and increasing the risk of esophageal squamous cell carcinoma (OR = 6.53; 95% CI = 2.78–15.33) [39].