We selected four of the novel potential USP15 binding partners HECT Domain Containing E3 Ubiquitin Protein Ligase 1 (HECTD1), Oxysterol Binding Protein-Like 3 (OSBPL3), and Kinesin Family Member 15 (KIF15), Regulator Of Microtubule Dynamics 3 (RMDN3) that seem to be implicated in cancer relevant molecular mechanisms [23–30]. The gene discussed is USP15; the disease is cancer.