A mesenchymal phenotype, characterised by low expression of E-cadherin (CDH1), high expression of vimentin (VIM) and high expression of EMT-inducing transcription factors, such as TWIST1, ZEB1, SNAI1 and SNAI2 (Figure 1B) moreover correlates with the expression of cancer stem cell markers CD44 and CD90 (Figure 1C). This evidence concerns the gene TWIST1 and cancer.