Univariate analysis identified several variables significantly associated with OS including BMI (HR: 1.87, 95%CI: 1.06-3.35, p=0.030), ECOG-PS (HR: 2.69, 95%CI: 3.35-14.34, p=0.003), T classification (HR: 6.16, 95%CI: 3.40-10.94, p<0.001), tumor size (HR:3.31, 95%CI: 1.79-6.50, p<0.001), nuclear grade (HR: 3.72, 95%CI: 1.97-6.73, p<0.001), tumor necrosis (HR: 4.12, 95%CI: 2.22-7.41, p<0.001), CRP (HR: 4.00, 95%CI: 2.26-7.10, p<0.001), the UISS (HR: 4.39, 95%CI: 2.39-8.61, p<0.001), the SSIGN (HR: 4.28, 95%CI: 2.42-7.56, p<0.001) and the COP-NLR (HR: 4.59, 95%CI: 2.59-8.14, p<0.001). This evidence concerns the gene CRP and neoplasm.