SMAD2 and cancer: Results revealed that M2 was able to downregulate many important signaling events in cancer progression such as EGF, PDGF, RAS, TGF-β, Wnt and Angiogenic pathways (Figure 3A), as well as some genes [22–26] such as Smad-2, VEGF, IGF, RIOK, FOXC1 etc [27–29] (Figure 3B) which are strongly connected to Epithelial to Mesenchymal transition (EMT), cell migration and metastasis.