In this experiment, we compared the gene expression profile of several samples: BRAF-mutated melanoma cell lines after a short-term vemurafenib treatment (A375, SKmel28, WM266-4), DMSO-treated cell lines, differentiated cells such as normal human melanocytes (NHM) and less differentiated cells such as pluripotent stem cell-derived neural crest cells (D1NC) generated in our laboratory [23, 24]. The gene discussed is BRAF; the disease is melanoma.