The eTFinFGs include RARA, RUNX1T1, PML, ERG, RUNX1, SFPQ, and TFE3. Alternatively, if a TF has a tMAII score of less than ‘-1.0’ and a DoF score of more than ‘8’, which is the threshold of high frequent gene fusions in our previous study, it indicates that the TF has a higher chance of generating FGs in different cancer types, with multiple partner genes, and multiple break points than observed. Here, RUNX1 is linked to cancer.