PLAU and neoplasm: Interestingly, a DETG that encodes the plasminogen activator, urokinase (PLAU), a known biomarker for tumor invasion, was consistently upregulated in samples positive for the four TFFGs (PML-RARA, RUNX1-RUNX1T1, TMPRSS2-ERG, and SFPQ-TFE3).