The up-regulated target genes of PML, through comparing 15 fusion-positive samples versus 155 fusion-negative samples, were ANXA8, APOA1, CCNA1, CRABP1, PLAU, PRKCA, and RPTOR. The overexpression of ANXA8 has been reported as associated with AML [19]. The gene discussed is PLAU; the disease is acute myeloid leukemia.