POU5F1 and gastric cancer: These results was consistent with some prvious studies showing some structural proteins include receptors, membrane channel proteins and enzymes like SRY (sex determining region Y)-box 2, serum gastrin, pepsinogen I and octamer-binding protein-4 (OCT4) plays a vital role in gastric cancer metastasis or differentiation and thereby in TNM staging of GC [26, 27].