TRPM7 and neuroblastoma: Due to the fact that TRPM7 is a calcium-permeable ion channel [22, 31, 32], and that low concentrations of FTY-720 inhibits TRPM7 but higher concentrations activates another TRP-like channel, experiments were performed to investigate the calcium signaling in NB cells treated with FTY-720, sphingosine and in control untreated cells.