NOX-A12 has been shown to inhibit SDF-1-induced chemotaxis of chronic lymphocytic leukemia (CLL) cells and conversely augment migration of CLL cells beneath a bone marrow stromal cell (BMSC) layer by disrupting the BMSC-generated SDF-1 gradient [35]. The gene discussed is CXCL12; the disease is B-cell chronic lymphocytic leukemia.