POLM and lung cancer: These were, among others, annotated to genes encoding cellular enzymes, i.e. PGD, GXYLT1, POLM, and DEAD box polypeptide 43 (DDX43), also known as HAGE (DEAD box helicase antigen), of which the latter has been shown to be an immunogenic cancer-specific antigen present in the protein level of different tumours including lung cancers [87].