BDNF and major depressive disorder: Antidepressants that decrease BDNF levels can be effective in treatment of depression, however can alter sleep pattern [16], which may increase GABAARs on the membrane of excitatory cortical neurons, while increase of slow wave sleep can return to baseline levels [17], while adenosine A1 receptors (A1R) plays a decisive role for antidepressant effects on sleep deprivation [18].