Interestingly, the phase II study entitled “Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation (ROSCO-CF)” is ongoing to assess the safety of increasing doses of (R)-Roscovitine in adult CF subjects chronically infected with Pseudomonas aeruginosa [71]. The gene discussed is CFTR; the disease is cystic fibrosis.