The downstream targets of VEGFR2, such as the PI3K/Akt pathway, is one of the most important carcinogenic pathways in many kinds of human cancers [30, 31], which is vital to tumorigenesis, proliferation, invasion, cell cycle progression, inhibition of apoptosis, angiogenesis, metastasis and chemoresistance in cancer cells [30, 32–35]. This evidence concerns the gene AKT1 and cancer.