HLA-B and hypersensitivity reaction disease: Indeed, various HLA specific alleles have been demonstrated to be directly involved in drug toxicities, such as HLA-B*57:01 with the abacavir-induced hypersensitivity reaction [33], HLA-B*15:02 with carbamazepine-induced Stevens–Johnson syndrome, and toxic epidermal necrolysis with high test sensitivity [34].