Elangovan et al. [24] documented that silencing AGER expression inhibited prostate tumor growth by activation of caspase-8 and caspase-3 death signaling and Radia et al. [16] reported that the blockage of AGER inhibited the proliferation of various subtypes of breast cancer via arresting cells in the G1 phase and inhibiting DNA synthesis. This evidence concerns the gene CASP8 and breast cancer.