Our results suggest that the MBL2 gene +4C>T locus Q allele, the CD14 gene T allele, the TNF-α gene T allele, the MBL2 +4C>T PQ genotype, the CD14-159C>T TT genotype, and the TNF-857 CT genotype are associated with increased spinal TB susceptibility in the Chinese population. This evidence concerns the gene MBL2 and tuberculosis.