The PLP-α-syn mouse, like other existing MSA models [4, 36, 49, 75], is based on the strategy of targeted overexpression of human α-syn in oligodendrocytes, which corresponds to the hypothesis raised by Asi and co-workers that MSA oligodendroglia may express more SNCA mRNA than control oligodendrocytes [2]. This evidence concerns the gene SNCA and multiple system atrophy.