The most striking example of such discrepancy was detected in a case of centenarian (102 years old, case 21, Table 1), which showed a clinical history of dementia, 3R tau-dominant brainstem NFTs, NFT stages V/VI, but neuritic plaque score 0 and the absence of Aβ deposition at the midbrain and pons (Fig. 6k). This evidence concerns the gene MAPT and dementia.