Given the known differential chemosensitivity of histological subtypes of OC [4], the clear potential for previous analyses to be confounded by superior response rate to co-administered platinum in BRCA1/2-associated OC [9], the limited predictive power of family history in predicting germline BRCA status in the presumed negative populations [26], and the known phenotypic overlap between germline and somatic BRCA1/2-inactivated OC [24, 27], there is a clear need for comparison of response rate to PLD monotherapy to tumour BRCA1/2 status in a histologically uniform OC cohort. The gene discussed is BRCA1; the disease is neoplasm.