On the grounds of our recent study establishing the association between the infection of P. gingivalis in esophageal epithelium and progression of ESCC, herein we investigate the serum levels of immunoglobulin G and A (IgG and IgA) for P. gingivalis and their clinical significance for the diagnosis and postoperative prognosis of ESCC. This evidence concerns the gene CD79A and esophageal squamous cell carcinoma.