Furthermore, 5 ESCC patients with higher levels of both IgG and IgA had the worst prognosis and the median OS for these 5 patients was 16.62 months versus 32.93 months of the other 75 patients (log-rank test, x2 = 8316, P = 0.004, Data now shown). This evidence concerns the gene CD79A and esophageal squamous cell carcinoma.