In contrast, the choice of the biological agent did not impact median OS in TP53 wild-type tumours (anti-EGFR: 36.7 months [95%-CI: 21.4-NA]; anti-VEGF: 27.3 months [19.1–38.4]; HR: 1.04 [95%-CI: 0.57–1.90]; p = 0.886; Fig. 4b). This evidence concerns the gene EGFR and neoplasm.