CCL2 and gout: 2015). Treatment of inflammation under hyperuricemia control is the major therapeutic approach. During inflammatory processes, several cytokines are released, i.e., TNF-α, TNF-β, iNOS and COX-2. Therefore, inhibition of these cytokines could be a promising anti-inflammation strategy. The anti-inflammatory effects of the combination of P. emblica, T. belerica and T. chebula in equal proportions, known as triphala, have been reported to inhibit expression of cytokines such as TNF-α, IL-1β, VEGF, MCP-1 and PGE2 in in vivo experimental gouty arthritis in rats (Kalaiselvan and Rasool 2015).