The antitumor mechanism of cSBL in malignant mesothelioma has been well-documented in H28 cells; it was revealed that cSBL treatment activates the caspase cascade, the proapoptotic Bcl-2 family proteins Bik and Bim, as well as JNK and p38 MAPKs, consequently inducing apoptosis in these cells. This evidence concerns the gene MAPK8 and malignant mesothelioma.