The efficacy of cSBL on malignant mesothelioma cells has previously been reported [34,35]; Even though cSBL hardly show cytotoxicity to normal mesothelial cell Met5A, it efficiently reduced the viability of H28 malignant mesothelioma cells, and exhibited synergistic effects with TRAIL and pemetrexed on these cells. Here, TNFSF10 is linked to malignant mesothelioma.