Furthermore, our AI tumorspheres showed a > 2-fold up-regulation of other proteins that are associated with an epithelial-to-mesenchymal transition (Tpi1, Pgk1, Hspa8, Hnrnpk, Nampt and Rho A) compared to the AD cells which could further explain the anchorage-independent growth and malignant properties of this population [28, 31]. Here, TPI1 is linked to Alzheimer disease.