To determine whether our AI tumorspheres were resistant to radio-therapy and small molecule inhibition of the PDGFRβ activity, compared to the AD cells, we subjected them to 2.5 Gy of radiation or 0.2 μM sutent treatment and measured their bio-function activity (proliferation, apoptosis, cytotoxicity, migration) after treatment. Here, PDGFRB is linked to Alzheimer disease.