Interestingly, atrophic stimuli affect skeletal muscle fiber types differently, with cachexia-associated atrophy leading to a greater reduction in slow fiber type size, while fast fiber types are more susceptible to atrophy when p53 is removed, possibly through the upregulation of the atrogin-1 ubiquitin ligase-mediated pathway [68,74]. This evidence concerns the gene FBXO32 and Cachexia.