It has been suggested that the findings are specific to the unique population with a high incidence of malaria (57%), severe anaemia < 5 g/dL (32%), and acidosis (base deficit > 8 mmol/L, 51%) with saline and albumin causing disease-specific deterioration and worsening of both anaemia and acidosis [34, 35]. The gene discussed is ALB; the disease is anemia (phenotype).