Tumors were annotated for their oestrogen receptor (ER) status (1 for recognizable level of ER or ER+, −1 otherwise or ER-), p53 mutational status (1 for mutation or p53+, and −1 for wild type or p53-) and grade of tumor (−1 for grade 1, 0 for grade 2, and 1 for grade 3). The gene discussed is ESR1; the disease is neoplasm.